Bone Growth in Inflammatory Condition

Peri-implantitis Clinical Trial

A prospective double blind randomized controlled trial that examined Pulsed Electromagnetic Field in treatment of peri-implantitis on patients that were treated with dental implants and crowns a few years ago

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One month after treating with MED, we saw a reduction of marginal bone loss which remains constant after 3 months follow-up

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Accelerated Osseointegration

Effect of the Pulsed Electromagnetic Field (PEMF) on Dental Implants Stability: A Randomized Controlled Clinical Trial

Randomized controlled clinical trial on 40 implants placed in 20 patients

  • Significant 13% increase in implant stability at test group Vs. 2% decrease in control over all time points
  • 50% difference in TNFα raise in 4 weeks after implantation
  • 25% difference in radiograph evaluation of marginal bone loss

Implant stability change from baseline in ISQ (Implant Stability Quotient)

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Solution for high-risk patients

A new device for improving dental implant anchorage: a histological and micro- computed tomography study in rabbit

Controlled preclinical study on New Zealand rabbit tibia with micro-CT and histology

  • 48% increase in Bone to Implant Contact (%OI)
  • 62% increase in trabecular bone volume density (BV/TV)
  • 73% increase in connectivity density (Conn. D)
  • 44% increase in the number of trabeculae (Tb.N)
  • 32% decrease in trabecular spacing (Tb.Sp)
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Clinical Oral Implants Research. 2016 Aug;27(8):935-42.

Controlling Bacterial Colonization Around Dental Implants

Controlled in-vitro study to assess the influence of (PEMF) on Periimplantitis and connection with bacterial biofilm

Antimicrobial effects of a pulsed electromagnetic field: an in vitro polymicrobial periodontal subgingival biofilm model

  • The mean total bacterial counts were lower in the Test group vs the control group (p < 0.05)
  • Antimicrobial effects on the bacterial species and can be used to control bacterial colonization around dental implants

Changes in bacterial biofilm around implant

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Biofouling Journal. 2020:1-8

Faster Recovery

Retrospective controlled clinical trial on 24 implants placed in 12 patients

Miniaturized Electromagnetic Device Abutment Improves Stability of Dental Implants

  • Significant difference in stability rates between groups
  • Similar effect at all bone types
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Journal of Craniofacial Surgery. 2019 Jun;30(4):1055-1057.

Controlled in-vitro study to assess osteoblasts formation in normal & inflammatory conditions

Pulsed electromagnetic fields increase osteogenesis commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study

  • Increase in MSC differentiation to osteoblasts
  • Increase in MSC differentiation to osteoblasts in
    inflammatory conditions
  • Enhanced mTOR signaling by increasing AKT, MAPP kinase, and RRAGA values
  • Increase in Runx, *osteopontin, osteonectin, osteocalcin collagen type I, wnt, foxO, ALP, BMP2 and BMP7 levels
  • Lower levels of *IL1B and higher levels of IL10
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Scientific Reports (Nature publishing) 2018 Mar 23;8(1):5108

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