Bone Growth in Inflammatory Condition

Peri-implantitis Clinical Trial

A prospective double blind randomized controlled trial that examined Pulsed Electromagnetic Field in treatment of peri-implantitis on patients that were treated with dental implants and crowns a few years ago

Accelerated Osseointegration

Effect of the Pulsed Electromagnetic Field (PEMF) on Dental Implants Stability: A Randomized Controlled Clinical Trial

Randomized controlled clinical trial on 40 implants placed in 20 patients

• Significant 13% increase in implant stability at test group Vs. 2% decrease in control over all time points
• 50% difference in TNFα raise in 4 weeks after implantation
• 25% difference in radiograph evaluation of marginal bone loss

Solution for high-risk patients

A new device for improving dental implant anchorage: a histological and micro- computed tomography study in rabbit

Controlled preclinical study on New Zealand rabbit tibia with micro-CT and histology

• 48% increase in Bone to Implant Contact (%OI)
• 62% increase in trabecular bone volume density (BV/TV)
• 73% increase in connectivity density (Conn. D)
• 44% increase in the number of trabeculae (Tb.N)
• 32% decrease in trabecular spacing (Tb.Sp)

Stimulate bone growth in inflammatory condition

Controlled in-vitro study to assess the influence of (PEMF) on bacterial biofilm colonization around implants

Antimicrobial effects of a pulsed electromagnetic field: an in vitro polymicrobial periodontal subgingival biofilm model

• The mean total bacterial counts were lower in the Test group vs the control group (p < 0.05)
• Antimicrobial effects on the bacterial species and can be used to control bacterial colonization around dental implants

Faster Recovery

Retrospective controlled clinical trial on 24 implants placed in 12 patients

Miniaturized Electromagnetic Device Abutment Improves Stability of Dental Implants

• Significant difference in stability rates between groups
• Similar effect at all bone types

Controlled in-vitro study to assess osteoblasts formation in normal & inflammatory conditions

Pulsed electromagnetic fields increase osteogenesis commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study

• Increase in MSC differentiation to osteoblasts
• Increase in MSC differentiation to osteoblasts in
  inflammatory conditions
• Enhanced mTOR signaling by increasing AKT, MAPP kinase, and RRAGA values
• Increase in Runx, *osteopontin, osteonectin, osteocalcin collagen type I, wnt, foxO, ALP, BMP2 and BMP7 levels
• Lower levels of *IL1B and higher levels of IL10